Definitely. The Pamir Highway is stunning in both directions, and we offer tours going either way.  You can start in Dushanbe, Tajikistan and end in Osh, Kyrgyzstan, or vice versa. Logistically, it’s the same route, just reversed.

Some travelers prefer starting in Dushanbe because it lets you gain altitude more gradually (Dushanbe is at ~700 m, Khorog ~2,100 m, then up to the high Pamir; whereas starting in Osh you jump to high altitude faster). Others prefer starting in Osh because you get the highest, most remote section done first and then “coast” to lower elevations. We can advise based on your entire Central Asia plan (for instance, if you’re coming overland from Uzbekistan, Osh is convenient; if flying into Tajikistan, Dushanbe start makes sense). All the permit and visa requirements apply regardless of direction. One thing to note: if you go Dushanbe -> Osh, you’ll need a multi-entry Tajik visa or two separate e-visas if you plan to dip into the Wakhan Valley and return to the main M41 (because that route exits and re-enters GBAO zone). We can help with this nuance. But for a standard one-way trip along M41 and Wakhan, a single entry visa + GBAO is fine either way. We arrange the vehicle to be where you need it – we have trusted drivers based in both Osh and Dushanbe.

In summary, yes, you can go either direction, and the experience in terms of sights is virtually the same. We might tweak overnight stops slightly depending on start point timing, but you won’t miss anything crucial. When you inquire, just let us know your preferred start city. Many of our clients actually start in Osh and finish in Dushanbe, then fly home from there or continue to Uzbekistan – but we’re totally flexible. The Pamirs welcome you either way!

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